Laryngopharyngeal reflux: The microbiota theory

Laryngopharyngeal reflux (LPR) is a prevalent disease associated with non-specific symptoms and findings. Many gray areas persist in the pathogenesis of LPR, diagnosis treatment. Symptoms are poorly correlated fiberoptic signs or hypopharyngeal-esophageal multichannel intraluminal impedance-pH monitoring The therapeutic response remains uncertain some resistant patients to medical surgical development LPR-symptoms findings may be related refluxate myriad gastroduodenal enzymes, which modify laryngopharyngeal oral microbiome leading mucosa maintenance recovery impairments. diet patient important because it impact composition foods known increase number hypopharyngeal events. events increased by autonomic nerve dysfunction that have an role persistence LPR-symptoms.